GLP-1s like Ozempic for Weight Cuts?

[pokemonster]

With easy access to GLP-1s such as ozempic, zepbound, wegovy, and easy access to cheap Chinese produced "research compounds", I was wondering if these are A. Banned and B. Tested for by the NCAA.

I can imagine this would be a major "life hack" for those cutting weight. Those of you who are on it, it's said to completely curb your appetite, increase metabolism, and make dropping weight easy as ever. Results look to speak for themselves. And from what I've read, the concerns over ""losing muscle" can be mitigated by a protein rich diet and weightlifting.

One would think this is perfect for athletes cutting weight. I've even seen bodybuilders throwing this into their stack to make their cuts easy. 

What are your thoughts on it? Think anyone's on it?

 

[Truzzcat]

I am not entirely aware of what GlP-1's do for metabolism I know they slow gastric emptying and curb appetite which of course greatly aids in weight loss. In the grand scheme of things though its simply replacing someone's discipline for lack of a better term. I would imagine it helps with sleep and feeling uncomfortable when you are starving which would be a big benefit. I do believe the compound was derived from growth hormone which I know is extremely difficult to test for because of its half-life which would lead me to believe glp's are the similar although they do require less frequent administration so perhaps, they are more detectable. 

[CHROMEBIRD]

Maybe helpful to guys like Jarrod Verkleeren, but it probably doesn't matter too much under current weight management protocol. While GLP-1s promote satiety, I thought they do it by actually slowing down your metabolic rate so the digestive process is prolonged and your blood glucose levels are smoothed out. This sounds like something @billyhoyle or @wrestlingnerd would know about. 

[pokemonster]

1 hour ago, CHROMEBIRD said:

Maybe helpful to guys like Jarrod Verkleeren, but it probably doesn't matter too much under current weight management protocol. While GLP-1s promote satiety, I thought they do it by actually slowing down your metabolic rate so the digestive process is prolonged and your blood glucose levels are smoothed out. This sounds like something @billyhoyle or @wrestlingnerd would know about. 

I don't think any of them slow down your metabolism from the studies I've seen, perhaps your basic metabolic rate will decrease as your body is lighter though. Eli Lilly is in Phase 3 for Retatrutide, which hits 3 receptors at once, GLP-1 (same as Ozempic), GIP (this plus GLP-1 = Tirzepatide / Zepbound), and Glucagon. The glucagon is said to increase fat burning and even increase your metabolic rate. It's not yet FDA approved but Googling it shows it's avaliable for purchase. Just for "research only". Not saying to hop on it, but I think this could be a cheat code for cutting weight if it's not tested for. This is based on quick research I've done, so feel free to correct me. 

[billyhoyle]

5 hours ago, CHROMEBIRD said:

Maybe helpful to guys like Jarrod Verkleeren, but it probably doesn't matter too much under current weight management protocol. While GLP-1s promote satiety, I thought they do it by actually slowing down your metabolic rate so the digestive process is prolonged and your blood glucose levels are smoothed out. This sounds like something @billyhoyle or @wrestlingnerd would know about. 

The issue with the GLP-1 agonists as PEDs is the muscle loss that accompanies the treatment (that's why the people taking it look so wacky and stand out with their body shape). There is some question as to whether the muscle loss is more diet related (people needing GLP-1 agonists tend to not be focusing on protein rich diets/resistance training) or inherent to the mechanism of the therapy.  

 

Some pharma companies are developing drugs to co-administer to preserve muscle mass (see: https://www.biospace.com/regeneron-looks-to-target-lucrative-weight-loss-market-with-muscle-preserving-antibodies). It's not clear whether this is really needed, since the health benefits are clearly there even with the muscle loss. 

 

 

[JimmyCinnabon]

17 hours ago, Truzzcat said:

I am not entirely aware of what GlP-1's do for metabolism I know they slow gastric emptying and curb appetite which of course greatly aids in weight loss. In the grand scheme of things though its simply replacing someone's discipline for lack of a better term. I would imagine it helps with sleep and feeling uncomfortable when you are starving which would be a big benefit. I do believe the compound was derived from growth hormone which I know is extremely difficult to test for because of its half-life which would lead me to believe glp's are the similar although they do require less frequent administration so perhaps, they are more detectable. 

I am starting compound tirzepatide today, which is a GLP-1 drug. To give you some more information it does curb your appetite by making you feel full most of the time and does slow the gastric emptying. It also affects the brain by removing what is called "food noise." Basically you don't think about food. At least not the way you normally would. It's just not on your mind so you aren't just salivating at the prospect of eating your next meal. It also makes you not want to drink alcohol so that is something I am looking forward to.

I am 44 years old now. I have lost absurd amounts of weight in my younger years and got into great shape in my early 30's but at this point in my life I want an easier solution to my problem. I've done it the hard way. Multiple times. I want the easy way this time.

My wife is a type-2 diabetic and has been on Ozempic for about a year now and has lost a lot of weight. Her A1C level has never been better since she was diagnosed with diabetes since she started Ozempic. It's truly a miracle drug. 

[jchapman]

1 hour ago, JimmyCinnabon said:

I am starting compound tirzepatide today, which is a GLP-1 drug. To give you some more information it does curb your appetite by making you feel full most of the time and does slow the gastric emptying. It also affects the brain by removing what is called "food noise." Basically you don't think about food. At least not the way you normally would. It's just not on your mind so you aren't just salivating at the prospect of eating your next meal. It also makes you not want to drink alcohol so that is something I am looking forward to.

I am 44 years old now. I have lost absurd amounts of weight in my younger years and got into great shape in my early 30's but at this point in my life I want an easier solution to my problem. I've done it the hard way. Multiple times. I want the easy way this time.

My wife is a type-2 diabetic and has been on Ozempic for about a year now and has lost a lot of weight. Her A1C level has never been better since she was diagnosed with diabetes since she started Ozempic. It's truly a miracle drug. 

How much do you weigh right now?

[666]

18 hours ago, pokemonster said:

With easy access to GLP-1s such as ozempic, zepbound, wegovy, and easy access to cheap Chinese produced "research compounds", I was wondering if these are A. Banned and B. Tested for by the NCAA.

I can imagine this would be a major "life hack" for those cutting weight. Those of you who are on it, it's said to completely curb your appetite, increase metabolism, and make dropping weight easy as ever. Results look to speak for themselves. And from what I've read, the concerns over ""losing muscle" can be mitigated by a protein rich diet and weightlifting.

One would think this is perfect for athletes cutting weight. I've even seen bodybuilders throwing this into their stack to make their cuts easy. 

What are your thoughts on it? Think anyone's on it?

 

My thoughts are this: I don't like it. I'm old school and weight dropping should consist ENTIRELY of 1) working out with regular sweats and plastic sweats at the same time, 2) running for hours in aforementioned plastic sweats until you smell like a moldy jock strap, 3) eating an entire bar of Ex-Lax and "browning" your brains out for a day before the match, 4) induced puking. Paddling the soles of one's feet to induce sweating is optional. 

Edited January 23 by 666

[JimmyCinnabon]

20 minutes ago, jchapman said:

How much do you weigh right now?

My guess is about 220lbs. I haven't stepped on a scale in a while but I will tonight before I take my first dose. For reference I am 5'8". My goal is 153lbs because for some reason that is where I think I look and feel my best. I was down to 144.6lbs in April of 2014, down from 235lbs and I think at that weight I looked a little too thin. 

[Fletcher]

Not performance-enhancing and not a safety risk, so NCAA shouldn't care.

[666]

5 hours ago, Fletcher said:

Not performance-enhancing and not a safety risk, so NCAA shouldn't care.

Yet they test for weed. 

[pokemonster]

5 hours ago, Fletcher said:

Not performance-enhancing and not a safety risk, so NCAA shouldn't care.

If that's the case, I don't see any reason why wrestlers aren't using this *I poop my pants, don't laugh at me* to cut weight. It absolutely would make it so much easier. 

[Fletcher]

43 minutes ago, 666 said:

Yet they test for weed. 

True. Could be considered performance-enhancing (gets rid of crippling anxiety for some), but I don't think that's why they test for it. 

[CHROMEBIRD]

11 hours ago, JimmyCinnabon said:

I am starting compound tirzepatide today, which is a GLP-1 drug. To give you some more information it does curb your appetite by making you feel full most of the time and does slow the gastric emptying. It also affects the brain by removing what is called "food noise." Basically you don't think about food. At least not the way you normally would. It's just not on your mind so you aren't just salivating at the prospect of eating your next meal. It also makes you not want to drink alcohol so that is something I am looking forward to.

The food noise thing is pretty wild. Is the psychological effect the result of the drug curbing your appetite, or is your appetite curbed because the drug eliminates brain noise? Kind of a chicken and egg thing.

[666]

11 hours ago, Fletcher said:

True. Could be considered performance-enhancing (gets rid of crippling anxiety for some), but I don't think that's why they test for it. 

I could see weed being performance enhancing if used before a hot dog eating contest but weed doesn't seem like it would help the reflexes all that much in a wrestling match.  I get what you are saying though. 

[JimmyCinnabon]

11 hours ago, CHROMEBIRD said:

The food noise thing is pretty wild. Is the psychological effect the result of the drug curbing your appetite, or is your appetite curbed because the drug eliminates brain noise? Kind of a chicken and egg thing.

 

It's actually both. It keeps the digested food in your GI track longer so that you feel full almost all of the time. On top of that it affects your brain chemistry in a way that you just don't think about food. I took my first dose around 5 PM last night. I had some mild nausea and a mild headache as a side effect. I will start to take my dose before I go to bed in the future so I don't even experience those side effects but I wanted to see what the side effects, if any, would be with my first dose. It was nothing that made me uncomfortable or anything like that. A couple of Tylenol and I was fine.

I feel fine this morning though. I do feel full but it's supposed to really kick in on days 2-3 so that will be tomorrow and Sunday. I planned it like this on purpose since the weekends are the hardest and I wanted the most benefit/effect on those days.

[HungusMungus]

I have been on Ozempic since October for my Beetus', it is not a quick fix weight loss drug it took 90 days to ramp up and I didn't see a weight loss change until recently. 

I don't see how this would benefit wrestlers, especially when this drug has been known to reduce muscle mass too. 

On top of that the nausea and lack of desire to eat does not mix well with training. 

On the other hand, amazing Beetus' drug, my A1C levels are almost normal again! 

[pokemonster]

1 hour ago, HungusMungus said:

I have been on Ozempic since October for my Beetus', it is not a quick fix weight loss drug it took 90 days to ramp up and I didn't see a weight loss change until recently. 

I don't see how this would benefit wrestlers, especially when this drug has been known to reduce muscle mass too. 

On top of that the nausea and lack of desire to eat does not mix well with training. 

On the other hand, amazing Beetus' drug, my A1C levels are almost normal again! 

Ehhh, many people post to the contrary and have immediate appetite suppression and immediate weight loss results. Lots of studies on the muscle mass effects and they're likely linked to people not being mindful of their protein intake and it's simply a result of consuming less calories, similar to what would happen during any cut.

As far as side effects, they're not universal. My gf has been on tirzepatide and has experienced immediate results, no side effects. In fact, she feels better than before. So I believe YMMV most definitely applies here.