Tony Ramos (133), Mark Ballweg (141) and Mike Evans (174) earned major decisions, and Nick Moore (165) won by fall.
Top-ranked Matt McDonough (125) extended his win streak to 40 matches by opening the dual with an 8-2 decision over Brenan Lyon. Ramos extended Iowa's team lead to 7-0 with five takedowns, a pair of points for stalling, one reversal and a point for riding time en route to a 15-4 win over Brandon Fifield. Ballweg then gave Iowa an 11-0 advantage and earned his team-best ninth major decision with a 14-4 win over Nicholas Trimble.
Michigan State (4-7, 0-4) cut Iowa's lead to 11-3 when Michael Kelly (149) dropped a 10-4 decision to Dan Osterman, but top-ranked Derek St. John (157) put Iowa back on the board with a 12-6 win over Ryan Watts.
Moore stretched Iowa's lead to 20-3 with a fall over Nick Proctor. He earned his third pin of the season after erasing a 2-0 deficit and building a 14-3 edge before flatting Proctor in 6:39.
Mike Evans earned his second straight major decision with a 12-2 win over Jordan Wohlfert at 174, and Nathan Burak improved to 3-1 in the Big Ten with a 7-4 win over Luke Jones at 197.
Michigan State's John Rizqallah picked up the Spartans' second win with a 6-3 decision over Ethen Lofthouse (184). Michigan State added six points to the final 27-12 team score when Iowa forfeited at 285 pounds.
The Hawkeyes return to the mat Jan. 16 at Minnesota. BTN will televise the dual beginning at 3 p.m.
125: #1 Matt McDonough (IA) dec. Brenan Lyon (MSU), 8-2; 3-0
133: #2 Tony Ramos (IA) major dec. Brandon Fifield (MSU), 15-4; 7-0
141: #9 Mark Ballweg (IA) major dec. Nicholas Trimble (MSU), 14-4; 11-0
149: Dan Osterman (MSU) dec. #17 Michael Kelly (IA), 10-4; 11-3
157: #1 Derek St. John (IA) dec. Ryan Watts (MSU), 12-6; 14-3
165: #18 Nick Moore (IA) pinned Nick Proctor (MSU), 6:39; 20-3
174: #6 Mike Evans (IA) major dec. Jordan Wohlfert (MSU), 12-2; 24-3
184: John Rizqallah (MSU) dec. #11 Ethen Lofthouse (IA), 6-3; 24-6
197: Nathan Burak (IA) dec. Luke Jones (MSU), 7-4; 27-6
285: #7 Mike McClure (IA) win by forfeit; 27-12